Table 1.
Passive and active membrane properties of VAL and VPM neurons in 21-d-old (presymptomatic) and 75-d-old (symptomatic) R6/2 and WT mice
| Capacitance (pF) | Input resistance (MΩ) | Time constant (ms) | RMP (mV) | Rheobase (pA) | |
|---|---|---|---|---|---|
| VAL | |||||
| 21 d | |||||
| WT-VAL (n = 16) | 173.2 ± 10.8 | 328.1 ± 31.2 | 4.2 ± 0.3 | −64.5 ± 1.4 | 566.3 ± 21.9 |
| R6/2-VAL (n = 14) | 125.2 ± 7.7*** | 334.0 ± 54.2 | 3.0 ± 0.3*** | −64.5 ± 1.5 | 396.4 ± 35.3** |
| 75 d | |||||
| WT-VAL (n = 16) | 136.9 ± 8.8†† | 245.3 ± 36.6 | 3.0 ± 0.2††† | −62.1 ± 0.8 | 360 ± 30.7††† |
| R6/2-VAL (n = 20) | 107.1 ± 5.9* | 460.2 ± 40.3***§ | 2.5 ± 0.1 | −63.4 ± 1.4 | 360 ± 29.2 |
| VPM | |||||
| 21 d | |||||
| WT-VPM (n = 13) | 175.2 ± 14.4 | 203.0 ± 34.1 | 3.8 ± 0.03 | −63.1 ± 1.1 | 439.6 ± 52.9 |
| R6/2-VPM (n = 16) | 167.0 ± 13.6 | 351.1 ± 46.5* | 3.7 ± 0.3 | −64.1 ± 1.2 | 463.1 ± 40.9 |
| 75 d | |||||
| WT-VPM (n = 17) | 151.1 ± 13.7 | 213.8 ± 29.5 | 3.2 ± 0.3 | −64.2 ± 0.9 | 365.3 ± 38.7 |
| R6/2-VPM (n = 21) | 79.2 ± 4.7***§§ | 387.8 ± 50.3** | 1.9 ± 0.1***§§§ | −59.3 ± 1.4** | 235.0 ± 29.9*§§§ |
Statistical significance was determined using two-way ANOVAs followed by Bonferroni post hoc tests. Symbols indicate the following: *, **, *** represent genotype-dependent statistically significant differences between cells in each age group and where p < 0.05, p < 0.01, and p < 0.001, respectively; ††, ††† represent statistical significance when comparing age-dependent differences in WT cells in each nucleus and where p < 0.01 and p < 0.001, respectively; §, §§, §§§ represent statistical significance when comparing age-dependent differences in R6/2 cells within each nucleus, and where p < 0.05, p < 0.01, and p < 0.001, respectively.