Table 2.
Changes in liver MMPs, TIMPs, RECK, TBARS, ROS, GSH and collagen in rats fed with MCD diet.
| C 2 wk | MCD 2 wk | C 4 wk | MCD 4 wk | C 8 wk | MCD 8 wk | |
|---|---|---|---|---|---|---|
| MMP-2 | 224.79 ± 33.38 | 282.50 ± 21.08 | 247.71 ± 28.71 | 396.04 ± 57.41 | 213.00 ± 27.95 | 491.01 ± 40.80 *,# |
| MMP-9 | 31.56 ± 13.37 | 43.95 ± 10.44 | 43.58 ± 5.99 | 132.34 ± 30.34 # | 38.91 ± 4.89 | 110.74 ± 8.75 *,# |
| TIMP-1 | 0.92 ± 0.14 | 0.55 ± 0.11 # | 1.23 ± 0.15 | 0.25 ± 0.06 # | 1.15 ± 0.18 | 0.24 ± 0.05 *,# |
| TIMP-2 | 0.62 ± 0.13 | 0.25 ± 0.03 # | 0.65 ± 0.07 | 0.18 ± 0.05 # | 0.56 ± 0.13 | 0.26 ± 0.05 # |
| RECK | 0.31 ± 0.09 | 1.02 ± 0.07 # | 0.25 ± 0.01 | 0.65 ± 0.16 # | 0.24 ± 0.06 | 0.62 ± 0.09 *,# |
| TBARS | 0.06 ± 0.01 | 0.13 ± 0.03 # | 0.06 ± 0.01 | 0.73 ± 0.12 # | 0.08 ± 0.01 | 2.02 ± 0.35 #,*,$ |
| ROS | 33,765.16 ± 9574.98 | 97,357.25 ± 6702.58 | 14,118.83 ± 1599.29 | 351,301.40 ± 57,221.08 | 48,229.00 ± 1778.59 | 624,931.40 ± 30,738.30 |
| GSH | 37.31 ± 1.49 | 19.33 ± 1.34 | 37.66 ± 2.53 | 16.18 ± 1.15 | 36.92 ± 2.51 | 17.99 ± 1.74 |
| Collagen | 1.66 ± 0.55 | 6.71 ± 1.90 # | 2.43 ± 1.26 | 13.03 ± 5.04 #,* | 2.87 ± 1.90 | 11.06 ± 5.1 #,* |
* p ≤ 0.05 versus MCD 2 wk; $ p ≤ 0.05 versus MCD 4 wk; # p ≤ 0.05 versus respective control. MMPs: DO/mg protein; TIMPs and RECK: A.U./Tubulin; TBARS and GSH: nmoL/mg protein; ROS: A:U; collagen, autofluorescence intensity as A.U.; weeks (wk).