Table 7.
Changes in fatty acids in rats fed MCD diet.
| C 2 wk | MCD 2 wk | C 4 wk | MCD 4 wk | C 8 wk | MCD 8 wk | |
|---|---|---|---|---|---|---|
| C 16:0, palmitic acid | 25.5 ± 1.5 | 23.6 ± 0.8 | 20.9 ± 0.5 | 21.9 ± 0.9 | 21.1 ± 1.6 | 21.0 ± 0.5 * |
| C 18:0, stearic acid | 15.2 ± 1.8 | 6.7 ± 0.4 # | 16.2 ± 0.8 | 6.8 ± 0.2 # | 17.1 ± 0.8 | 6.1 ± 0.3 # |
| C 18:1 n7, vaccenic acid | 3.3 ± 0.7 | 2.2 ± 0.2 | 3.2 ± 0.3 | 2.0 ± 0.1 # | 4.6 ± 0.3 | 1.8 ± 0.1 #,* |
| C 18:1, n9 oleic acid | 17.1 ± 1.7 | 23.2 ± 0.9 # | 17.8 ± 1.0 | 21.6 ± 0.9 | 17.3 ± 1.2 | 20.3 ± 0.9 |
| C 18:2 n6, linoleic acid | 20.5 ± 1.3 | 30.3 ± 0.5 #,$ | 19.0 ± 0.6 | 28.2 ± 0.4 #,* | 16.6. ± 0.7 | 27.0 ± 0.3 #,* |
| C 20:4 n6, arachidonic acid | 11.5 ± 1.2 | 6.0 ± 0.6 # | 13.0 ± 0.9 | 7.7 ± 0.4 # | 17.8 ± 1.6 | 8.9 ± 0.6 #,* |
| C 22:4 n6 docosatetraenoic acid | 0.5 ± 0.1 | 1.1 ± 0.1 # | 0.8 ± 0.1 | 2.3 ± 0.3 # | 1.0 ± 0.3 | 2.8 ± 0.1 #,* |
| C 22:5 n3, docosapentaenoic acid | 0.4 ± 0.1 | 0.8 ± 0.1 # | 0.4 ± 0.1 | 0.3 ± 0.1 * | 0.3 ± 0.1 | 0.2 ± 0.1 * |
| C 22:6 n3, docosahexaenoic acid | 1.5 ± 0.2 | 0.8 ± 0.1 # | 0.9 ± 0.1 | 2.2 ± 0.2 * | 2.0 ± 0.3 | 4.0 ± 0.3 #,*,$ |
* p ≤ 0.05 versus MCD 2 wk; $ p ≤ 0.05 versus MCD 4 wk; # p ≤ 0.05 versus respective control. Fatty acids are expressed as a percentage of total fatty acids in the liver; weeks (wk).