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. 2022 Jun 8;23(12):6425. doi: 10.3390/ijms23126425

Table 1.

Generation of DOX-resistant bone sarcoma cell lines.

Cell Line
(Tumor Type)		 Initial IC50 (µM) Drug-Resistance Induction Protocol Final IC50 (µM) RI
Step 1 Step 2 Step 3 Step 4 Step 5 Step 6 Step 7 Step 8
T-CDS-17#4
(chondros.)		 0.088 0.008 µM (IC20)
1 month		 0.016 µM
(2 × IC20)
1 month		 0.032 µM
(4 × IC20)
1 month		 0.064 µM
(8 × IC20)
1 month		 - - - - 1.3 15.2
MG-63
(osteos.)		 0.061 0.019 µM (IC20)
1 month		 0.038 µM
(2 × IC20)
1 month		 0.076 µM
(4 × IC20)
1 month		 0.152 µM
(8 × IC20)
1 month		 0.304 µM
(16 × IC20)
1 month		 - - - 1.4 23.7
Saos-2
(osteos.)		 0.037 0.006 µM (IC20)
1 month		 0.012 µM
(2 × IC20)
1 month		 0.024 µM
(4 × IC20)
1 month		 - - - - - 1.7 44.9
143-B
(osteos.)		 0.049 0.010 µM (IC20)
1 month		 0.020 µM
(2 × IC20)
1 month		 0.040 µM
(4 × IC20)
1 month		 0.080 µM
(8 × IC20)
1 month		 0.160 µM
(16 × IC20)
1 month		 0.320 µM
(32 × IC20)
1 month		 0.640 µM
(64 × IC20)
1 month		 1.280 µM
(128 × IC20)
1 month		 6.4 131.4

Abbreviations: chondros, chondrosarcoma; osteos, osteosarcoma.