Table 2.
Comparison of pathological parameters between CLDN4-methylation high and low cases.
| Parameter | CLDN4 Methylation (1) | p | ||
|---|---|---|---|---|
| High | Low | |||
| Number | 11 | 12 | ||
| Grade (2) | Low | 1 | 0 | NS |
| High | 10 | 12 | ||
| pT (3) | pT1 | 10 | 10 | NS |
| pT2 | 1 | 2 | ||
| INF (4) | a/b | 11 | 5 | 0.0046 |
| c | 0 | 7 | ||
| Ly/V (5) | - | 11 | 4 | 0.0006 |
| + | 0 | 9 | ||
| Reurrence (6) | 3 | 10 | 0.0123 | |
(1) Methylation high, cases belonging to the upper 50% of methylation percentage; methylation low, cases belonging to the lower 50% of methylation percentage. (2) Histological grade low, G1-2; high, G3 according to TNM classification system [18]. (3) pT, primary tumor; pT1, subepithelial invasion; pT2, muscle invasion according to TNM classification system [18]. (4) INF, tumor infiltrative pattern into the surrounding tissues; INFa, expanding growth with a distinct border; INFb, intermediate pattern between INFa and INFc; INFc, infiltrative growth with no distinct border. (5) Ly/V, capillary invasion; Ly, lymphatic invasion; V, venous invasion. (6) Recurrence, local recurrence after transurethral resection.