Table 4.
IC50 values [μM] and resistance factors (RF) for ovarian cancer cell lines and their resistant analogues (-cis), and lung cancer cell line A549 for compounds M1–6 *.
| Compound | SKOV3 | SKOV3cis | RF SKOV3 | A2780 | A2780cis | RF A2780 | A549 |
|---|---|---|---|---|---|---|---|
| Ni1 | 5.8 (±0.6) | 6.8 (±3.0) | 1.2 | 3.5 (±0.3) | 5.0 (±1.1) | 1.4 | 5.4 (±0.1) |
| Ni2 | 36.6 (±9.3) | 11.0 (±2.1) | 0.3 | 7.7 (±2.0) | 10.7 (±6.0) | 1.4 | 5.2 (±1.0) |
| Ni3 | 7.1 (±3.7) | 7.8 (±3.4) | 1.1 | 8.0 (±4.8) | 5.4 (±0.8) | 0.7 | 3.8 (±0.0) |
| Ni4 | 9.2 (±5.1) | 6.7 (±2.0) | 0.7 | 3.8 (±0.1) | 5.4 (±1.0) | 1.4 | 7.7 (±2.2) |
| Ni5 | 10.3 (±5.0) | 15.9 (±2.3) | 1.5 | 10.4 (±0.8) | 6.6 (±0.3) | 0.6 | 8.1 (±3.9) |
| Ni6 | 8.6 (±4.6) | 7.6 (±0.2) | 0.9 | 8.8 (±8.1) | 10.8 (±6.5) | 1.2 | 9.7 (±6.3) |
| Pd1 | 13.7 (±8.2) | 4.4 (±1.3) | 0.3 | 3.1 (±0.0) | 4.7 (±2.3) | 1.5 | 2.8 (±1.2) |
| Pd2 | 5.8 (±4.1) | 3.7 (±0.8) | 0.6 | 3.1 (±0.6) | 4.7 (±2.3) | 1.5 | 8.7 (±8.2) |
| Pd3 | 3.8 (±1.0) | 5.4 (±3.1) | 1.4 | 3.1 (±0.0) | 3.2 (±0.1) | 1.0 | 4.5 (±1.7) |
| Pd4 | 5.7 (±2.5) | 3.3 (±0.2) | 0.6 | 3.1 (±0.0) | 3.1 (±0.0) | 1.0 | 6.3 (±2.4) |
| Pd5 | 12.9 (±7.1) | 8.6 (±3.4) | 0.7 | 4.3 (±0.5) | 6.2 (±2.0) | 1.4 | 9.8 (±1.3) |
| Pd6 | 8.9 (±1.0) | 2.8 (±0.2) | 0.3 | 12.7 (±1.0) | 6.4 (±0.4) | 0.5 | 2.4 (±0.4) |
| Pt1 | 6.6 (±2.1) | 13.7 (±7.5) | 2.1 | 3.4 (±0.0) | 8.5 (±3.4) | 2.5 | 4.2 (±0.7) |
| Pt2 | 28.2 (±7.3) | 37.9 (±0.6) | 1.3 | 50.9 (±15.4) | 45.2 (±9.6) | 0.9 | 7.4 (±2.5) |
| Pt3 | 38.7 (±5.1) | 28.2 (±6.6) | 0.7 | 16.8 (±18.9) | 67.9 (±28.4) | 4.0 | 43.0 (±2.9) |
| Pt4 | 7.7 (±0.6) | 5.6 (±1.2) | 0.7 | 5.4 (±3.0) | 4.0 (±0.9) | 0.7 | 4.8 (±1.3) |
| Pt5 | 12.0 (±7.2) | 21.2 (±8.0) | 1.8 | 4.7 (±1.0) | 24.0 (±0.6) | 5.1 | 8.0 (±0.8) |
| CDDP | 3.8 (±2.8) | 13.5 (±4.4) | 3.6 | 1.3 (±0.2) | 6.1 (±2.1) | 4.7 | (±2.6) |
* IC50-values ≤ IC50-values CDDP or RF < 1 are marked in red.