Table 6.
IC50 values [μM] for ovarian cancer cell lines and lung cancer cell line A549 for all 2 compounds *.
| Compound | SKOV3 | SKOV3cis | RF SKOV3 | A2780 | A2780cis | RF A2780 | A549 |
|---|---|---|---|---|---|---|---|
| L213 | 101.2 (±9.2) | 90.2 (±3.1) | 0.9 | 53.0 (±12.4) | 24.1 (±7.2) | 0.5 | 129.7 (±13.6) |
| Ni2 | 36.6 (±9.3) | 11.0 (±2.1) | 0.3 | 7.7 (±2.0) | 10.7 (±6.0) | 1.4 | 5.2 (±1.0) |
| Pd2 | 5.8 (±4.1) | 3.7 (±0.8) | 0.6 | 3.1 (±0.6) | 4.7 (±2.3) | 1.5 | 8.7 (±8.2) |
| Pt2 | 28.2 (±7.3) | 37.9 (±0.6) | 1.3 | 50.9 (±15.4) | 45.2 (±9.6) | 0.9 | 7.4 (±2.5) |
| Ptdmso213 | 28.8 (±4.9) | 20.1 (±3.0) | 0.7 | 19.8 (±1.6) | 21.0 (±3.3) | 1.1 | 24.2 (±2.0) |
| Ru242 | 22.4 (±9.6) | 17.8 (±0.9) | 0.8 | 16.4 (±3.3) | 15.0 (±2.9) | 0.9 | 15.3 (±8.1) |
| Os242 | 8.8 (±4.4) | 0.6 (±0.5) | 0.1 | 0.4 (±0.1) | 2.1 (±1.5) | 5.3 | 6.2 (±5.8) |
| CDDP | 3.8 (±2.8) | 13.5 (±4.4) | 3.6 | 1.3 (±0.2) | 6.1 (±2.1) | 4.7 | 7.6 (±2.6) |
* IC50-values ≤ IC50-value CDDP or RF < 1 are marked in red.