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. 2022 Jun 10;23(12):6534. doi: 10.3390/ijms23126534

Figure 2.

Figure 2

NGS-based discovery of miRNA changes in serum and ulna bone tissue of ZDF rats compared to WT rats under placebo treatment. (A,B) Volcano plots depict the log2-transformed fold change and log10-transformed adjusted p-values for the contrast (WT placebo, n = 5; ZDF placebo, n = 5) in both serum and ulna bone compartments. miRNA effects with Benjamini–Hochberg-adjusted p-values < 0.2 (FDR < 20%) are highlighted as separate group in red. (C) Comparison of miRNAs dysregulated in serum and in ulna bone (FDR threshold of 0.2). VENN diagram with the overlapping miRNA between the two compared lists corresponding to the miRNAs dysregulated in the ZDF model in serum (left circle) and ulna bone tissue (right circle). miR-199a-3p that is dysregulated in the ZDF model in both compartments is highlighted in red.