Figure 6.

SBP-101 results in decreased polyamine content in the cells of the ascites fluid of treated mice. Ascites was drained from a subset of untreated mice and mice treated with 24 mg/kg SBP-101 (3× alternating weeks) 52 days post-VDID8⁺ injection. Red blood cells were lysed from drained ascites fluid, and the remaining cells were analyzed for polyamine content by HPLC. There was no significant difference in putrescine levels between treated and untreated mice (A). Spermidine levels in the ascites cells were significantly decreased in SBP-101-treated mice with a p-value of 0.008 (B). Spermine levels were also lower in the ascites cells of treated mice, though the observed decrease was not statistically significant (p-value = 0.0534) (C). Overall polyamine levels were significantly lower in SBP-101-treated mice (p-value = 0.014) (D). Significance symbols are as follows: ns = not significant (p-value > 0.05); * = p-value < 0.05; ** = p-value < 0.01.