TABLE 1.
List of lncRNAs and their function in osteosarcoma
| Oncogenic | Tumor suppressor | Targets (gene/protein/signaling pathway or miRNAs) |
|---|---|---|
| DANCR | EZH2/p21 p27; miR-335-5p and miR-1972/ROCK1 | |
| PVT1 | MYC; ALKBH5-PVT1 | |
| ZFAS1 | BMI1 and ZEB2 | |
| ANRIL | miR-125a-5p/STAT3 | |
| MALAT-1 | EZH2/β-catenin and E-cadherin; PI3K/AKT; RhoA/ROCK; miR-509/Rac1; miR-142-3p/miR-129-5p/HMGB1; miR-140-5p/HDAC4 | |
| SNHG10 | Wnt/β-catenin | |
| AFAP1-AS1 | RhoC/ROCK1/p38MAPK/Twist1; miR-497/IGF1R | |
| HOTAIR | miR-126/CDKN2A/DNMT1; PRC2/HOXD | |
| KCNQ1OT1 | KCNQ1/DNMT1 | |
| ZEB1-AS1 | ZEB1 | |
| FOXD2-AS1 | EZH2/P21 | |
| HOXD-AS1 | EZH2/P57 | |
| FOXP4-AS1 | LSD1 and EZH2, LATS1 | |
| MIR100HG | EZH2, LATS1, LATS2, Hippo signaling pathway | |
| B4GALT1-AS1 | YAP | |
| H19 | Yap, Hedgehog signaling | |
| AC011442.1 | AMPK and hedgehog signaling | |
| MEG3 | miR-361-5p/FOXM1, miR-664a; miR-127/ZEB1; Notch and TGF-β | |
| HIF1α-AS1 | BRG1 | |
| p21 (TRP53COR1) | miR-130b; PTEN | |
| CEBPA-AS1 | Notch signaling pathway, NCOR2 | |
| EPIC1 | MEF2D | |
| NBAT1 | miR-21/PTEN/PDCD4/TPM1/RECK | |
| BLACAT1 | STAT3 | |
| NEAT1 | G9a-DNMT1-Snail (E-cadherin) |