Table 5.
Survival of the whole cohort of patients with NB in relation to MAPK3 gene-expression values, evaluated by the multivariable Cox regression model.
| Overall Survival | Event Free Survival | |||||
|---|---|---|---|---|---|---|
| Gene Expression | HR | 95% CI | p | HR | 95% CI | p |
| Median | 0.021 | 0.704 | ||||
| ≤3.836 (reference) | 1 | - | 1 | - | ||
| >3.836 | 1.4 | 1.0–1.8 | 1.0 | 0.83–1.3 | ||
| Tertiles | 0.094 * | 0.728 * | ||||
| ≤3.637 (reference) | 1 | - | 1 | - | ||
| 3.637–4.035 | 1.0 | 0.74–1.4 | 0.97 | 0.74–1.3 | ||
| >4.035 | 1.3 | 0.96–1.8 | 1.1 | 0.80–1.4 | ||
HR: Hazard ratio. Multivariable analysis: HRs are adjusted by MYCN status, age, and stage at diagnosis. * Test for trend.