Table 1.

Main effect of time point, age, and genotype, and their interaction in Clock, Bmal1, Per2, Chrono, Rev-erbα, and Rorα transcripts. The F and p values for the main effect of time point, age, and genotype, and their interaction for each gene were analyzed by Multifactorial-ANOVA. A significant effect was considered when p value < 0.05.

Multifactorial Anova Analysis
Transcript	Main Effect of Time Point		Main Effect of Age		Main Effect of Genotype		Time Point × Age × Genotype Interaction
	F (3,59)	p Value	F (4,59)	p Value	F (1,59)	p Value	F (12,59)	p Value
Clock	81.80	<0.001	47.60	<0.001	9.87	<0.01	6.33	<0.001
Bmal1	781.11	<0.001	83.88	<0.001	9.14	<0.05	8.37	<0.001
Per	23.31	<0.001	38.11	<0.001	42.17	<0.001	10.34	<0.001
Chrono	744.15	<0.001	179.12	<0.001	33.91	<0.001	34.34	<0.001
Rev-erbα	342.37	<0.001	8.38	<0.001	No effect		8.02	<0.001
Rorα	9.51	<0.001	16.34	<0.001	19.92	<0.001	14.02	<0.001