Table 1.
Clinical trials of MSC-derived Exosomes.
| # | NCT Number | Condition or Disease | Phase | Sponsor | Brief Summary |
|---|---|---|---|---|---|
| 1 | NCT02138331 | Diabetes Mellitus Type 1 | Phase 2, Phase 3 | General Committee of Teaching Hospitals and Institutes, Egypt | Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus |
| 2 | NCT03384433 | Cerebrovascular Disorders | Phase 1, Phase 2 | Isfahan University of Medical Sciences, Iran | Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke |
| 3 | NCT03437759 | Macular Holes | Early Phase 1 | Tianjin Medical University, China | To assess the safety and efficacy of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exos) for promoting healing of large and refractory macular holes (MHs). |
| 4 | NCT03608631 | Metastatic Pancreatic Adenocarcinoma | Phase 1 | M.D. Anderson Cancer Center, US | iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation |
| 5 | NCT04173650 | Dystrophic Epidermolysis Bullosa | Phase 1, Phase 2 | Aegle Therapeutics, US | MSC EVs in Dystrophic Epidermolysis Bullosa |
| 6 | NCT04276987 | Coronavirus | Phase 1 | Ruijin Hospital, China | A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia |
| 7 | NCT04313647 | Healthy | Phase 1 | Ruijin Hospital, China | A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers |
| 8 | NCT04388982 | Alzheimer Disease | Phase 1, Phase 2 | Ruijin Hospital, China | Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease |
| 9 | NCT04491240 | SARS-CoV-2 PNEUMONIA | Phase 2 | State-Financed Health Facility, Russia | Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia |
| 10 | NCT04602442 | SARS-CoV-2 PNEUMONIA | Phase 2 | State-Financed Health Facility, Russia | Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia |
| 11 | NCT04747574 | SARS-CoV-2 | Phase 1 | Tel-Aviv Sourasky Medical Center, Israel | Evaluation of the Safety of CD24-Exosomes in Patients With COVID-19 Infection |
| 12 | NCT05060107 | Osteoarthritis, Knee | Phase 1 | Universidad de los Andes, Chile | Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis |
| 13 | NCT05216562 | SARS-CoV2 Infection | Phase 2 | Dermama Bioteknologi Laboratorium, Indonesia | Efficacy and Safety of EXOSOME-MSC Therapy to Reduce Hyper-inflammation In Moderate COVID-19 Patients |
| 14 | NCT05261360 | Knee; Injury, Meniscus | Phase 2 | Eskisehir Osmangazi University, Turkey | Clinical Efficacy of Exosome in Degenerative Meniscal Injury |
| 15 | NCT05402748 | Fistula Perianal | Phase 1, Phase 2 | Tehran University of Medical Sciences, Iran | Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Anal Fistula |
Searched by ClinicalTrials.gov (https://clinicaltrials.gov/ct2/home, accessed on 1 June 2022).