Table 2.
Minimum inhibitory concentration (MIC) of antibiotics owing to TZ NC against the type S. epidermidis strain.
| Antibiotics | Acronym | Subclass | MIC (μg·mL−1) 1 | |
|---|---|---|---|---|
| −TZ | +TZ | |||
| Ampicillin | AMP | β-lactam | 0.125 | 0.0625 |
| Chloramphenicol | CHL | Amphenicol | >4 | 4 |
| Ciprofloxacin | CIP | Fluoroquinolone | <0.25 | <0.25 |
| Clindamycin | CLI | Lincosamide | <0.125 | <0.125 |
| Daptomycin | DAP | Cyclic lipopeptide | >1 | 1 |
| Erythromycin | ERY | Macrolide | 0.5 | 0.25 |
| Gentamicin | GEN | Aminoglycoside | <0.5 | <0.5 |
| Levofloxacin | LEVO | Fluoroquinolone | 0.25 | 0.125 |
| Linezolid | LZD | Oxazolidinone | >2 | 1 |
| Moxifloxacin | MXF | Fluoroquinolone | 0.125 | 0.125 |
| Nitrofurantoin | NIT | Nitrofuran | 16 | <8 |
| Oxacillin +2%NaCl |
OXA+ | β-lactam | 0.125 | 0.125 |
| Penicillin | PEN | β-lactam | 0.25 | 0.0625 |
| Quinupristin/ Dalfopristin |
SYN | Lincosamide | <0.125 | <0.125 |
| Rifampin | RIF | Rifampicin | <0.125 | <0.125 |
| Streptomycin | STR | Aminoglycoside | <250 | <250 |
| Tetracycline | TET | Tetracycline | >4 | >4 |
| Tigecycline | TGC | Tetracycline | 0.125 | 0.03 |
| Trimethoprim/sulfamethoxazole | SXT | Co-trimoxazole | 0.25/4.75 | 0.5/9.5 |
| Vancomycin | VAN | Glycopeptide | 2 | 2 |
1 MIC values of the antibiotics were determined using SensititreTM Gram Positive MIC plate (Cat. No. GPALL1F, Thermo Fisher Scientific, Waltham, MA, USA) with a total volume of 200 μL. Three independent experiments were performed with ATCC 14990 cells using the 96-well platform as shown in Figure S7. Antibiotics with enhanced antibacterial activity owing to TZ NC are indicated in bold.