Table 2.
Description and function of interested genes.
| Symbol | Gene Name | GenBank Accession Numbers |
Functions |
|---|---|---|---|
| cGAS-STING pathway | |||
| cGAS | Cyclic GMP-AMP synthase | NM_138441 | Catalyzes the formation of cyclic GMP-AMP from ATP and GTP and plays a key role in innate immunity. |
| STING | Stimulator of interferon genes; transmembrane protein 173 | NM_198282 | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). |
| TBK1 | TANK binding kinase 1 | NM_013254, XM_005268809, XM_005268810 | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. |
| IRF3 | Interferon regulatory factor 3 | NM_001197122, NM_001197123, NM_001197124, NM_001197125, NM_001197126, NM_001197127, NM_001197128, NM_001571, XM_006723197, XM_006723198, XM_017023766, XM_017023767 | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. |
| NFkB2 | Nuclear factor kappa B subunit 2 | NM_001077494, NM_001261403, NM_001288724, NM_001322934, NM_001322935, NM_002502 | Transcription factor produced at the endpoint of many signal transduction processes relating to inflammation, immunity, differentiation, cell growth, tumorigenesis, and apoptosis. |
| IFN-a | Interferon alpha | NM_006900, NM_024013 | Stimulates production of a protein kinase and an oligoadenylate synthetase for antiviral activities. |
| CANCER-RELATED | |||
| ABCC1 | ATP-binding cassette, subfamily C |
NM_004996 | Known as MRP1 (multidrug resistance protein 1). Member of the ATP binding cassette family that transports molecules across membranes. Mutations in ABCC1 N-glycosylation connected with cisplatin resistance. |
| ALK1 | Activin receptor-like kinase | NM_000020 | Type I cell-surface receptor for TGF-beta superfamily of ligands. Shares similar domain structures in serine-threonine kinase subdomains with other activin receptor-like kinase proteins. |
| BRCA1 | Breast cancer Type 1 susceptibility protein | NM_007294 | Nuclear phosphoprotein that acts as a tumor suppressor by maintaining genomic stability. Involved in transcription, DNA repair of double-stranded breaks, and recombination. |
| CDKN1A/ P21 |
Cyclin-dependent kinase inhibitor 1A/p21 | NM_000389, NM_00122077, NM_00122077, NM_078467, NM_001291549 | Plays a critical role in the cellular response to DNA damage and cisplatin toxicity. Mediates cell cycle arrest. Is cyto-protective. |
| CYP51A | Cytochrome P450, family 51, subfamily A, polypeptide 1 | NM_000786, NM_001146152 | Member of the cytochrome P450 enzyme family of monooxygenases. |
| DHRS2/ HEP27 |
Dehydrogenase/ reductase (SDR Family) member 2 |
NM_182908, NM_005794 | NADPH-dependent dicarbonyl reductase activity; Mitochondrial matrix protein. Inhibits MDM2 and stabilizes p53. |
| EGFR | Epidermal growth factor receptor | NM_005228 | Triggers cell proliferation when bound to epidermal growth factor. |
| ERBB2 | Erb-b2 receptor tyrosine kinase 2 | NM_004448 | Member of epidermal growth factor receptor family of receptor tyrosine kinases. Stabilizes binding of epidermal growth factor to receptor. |
| ERCC1 | Excision repair cross-complementation group 1 | NM_001166049, NM_001983, NM_202001 | Nucleotide excision repair formed by electrophilic compounds such as cisplatin. Forms a heterodimer with XPF endonuclease. Involved in recombination DNA repair, inter-stand crosslink, and lesion repair. |
| APOPTOSIS | |||
| BAX | BCL2-associated X protein | NM_001291429, NM_001291428, NM_001291430, NM_138761, NM_004324, NM_138764, NM_001291431, NM_138763 | Associates and forms a heterodimer with BCL2. Functions in apoptotic behavior by opening the mitochondrial voltage dependent anion channel, leading to loss of membrane potential and opening of cytochrome C. |
| CASP3 | Caspase-3 | NM_004346, NM_032991 | Effector caspase; Activated by caspases 8, 9 and 10; Effects caspases 6, 7, 9. Belongs to family of proteases involved in apoptosis. Synthesized as inactive precursors and therefore need activation. |
| CASP9 | Caspase-9 | NM_001229, NM_032996, XM_005246014 | Part of the apoptosome protein complex formed during apoptosis. Mitochondrial caspase activation. |
| HOUSEKEEPERS | |||
| HPRT1 | Hypoxanthine phosphor-ribosyl-transferase 1 | NM_000194 | Transferase catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. |
| HMBS | Hydroxy-methylbilane synthase | NM_000190, NM_001024382, NM_001258208, NM_001258209 | Member of the HMBS superfamily. Third enzyme of heme biosynthetic pathway; catalyzes head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. |
GenBank Accession Numbers and Functions from Uniprot.org.