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. 2022 Jun 11;23(12):6547. doi: 10.3390/ijms23126547

Figure 2.

Figure 2

Somatic alterations associated with cell-cycle-related genes in breast cancer genomic datasets. Oncoprint representing the status of 10 genes—ERBB2, RB1, CCND1, CCND2, CCND3, CDK4, CDKN1A, CDKN1B, CDKN2A, and CDKN2B—in 6198 patients/6609 samples in four studies: Breast Cancer (METABRIC, Nature 2021 & Nat Commun 2016) [94,95,97], Breast Cancer (MSK, Cancer Cell 2018) [96], Breast Invasive Carcinoma (TCGA, Cell 2015) [93], and Metastatic Breast Cancer (MSK, Cancer Discovery 2021). Queried genes are altered in 2444 (39%) of queried patients and 2600 (39%) of queried samples. Genetic alterations are depicted. We acknowledge cBioPortal for Cancer Genomics (https://www.cbioportal.org/, accessed on 30 November 2021), which provides a web resource for exploring, visualizing, and analyzing multi-dimensional cancer genomics data [100,101]. We acknowledge TCGA Research Network for generating the TCGA datasets (https://www.cancer.gov/tcga, accessed on 30 November 2021).