Table 1.
Clinicopathological characteristics of the patients with stage II/III gastric cancer in terms of perineural invasion.
| Parameters | Total | Perineural Invasion | p Value | |
|---|---|---|---|---|
| Negative | Positive | |||
| Number | 1913 | 820 (42.9) | 1093 (57.1) | |
| Age (year), mean ± SD |
63.68 ± 13.48 | 65.01 ± 12.75 | 62.68 ± 13.92 | <0.001 |
| ≤65 | 935 | 374 (45.6) | 561 (51.3) | 0.013 |
| >65 | 978 | 446 (54.4) | 532 (48.7) | |
| Sex | 0.040 | |||
| Male | 1186 | 530 (64.6) | 656 (60.0) | |
| Female | 727 | 290 (35.4) | 437 (40.0) | |
| Tumor size (cm), mean ± SD |
5.06 ± 2.84 | 4.82 ± 2.63 | 5.23 ± 2.98 | 0.002 |
| Location | 0.014 | |||
| Upper | 382 | 144 (17.6) | 238 (21.8) | |
| Middle | 344 | 155 (18.9) | 189 (17.3) | |
| Lower | 1119 | 501 (61.1) | 618 (56.5) | |
| Entire | 56 | 15 (1.8) | 41 (3.8) | |
| Other | 12 | 5 (0.6) | 7 (0.6) | |
| Number of LNs retrieved, mean ± SD |
36.50 ± 16.78 | 35.36 ± 16.38 | 37.35 ± 17.03 | 0.010 |
| Type of gastrectomy | <0.001 | |||
| Total | 608 | 220 (26.8) | 388 (35.5) | |
| Partial | 1305 | 600 (73.2) | 705 (64.5) | |
| T status | <0.001 | |||
| T1 | 64 | 63 (7.7) | 1 (0.1) | |
| T2 | 164 | 108 (13.2) | 56 (5.1) | |
| T3 | 382 | 165 (20.1) | 217 (19.9) | |
| T4a | 1161 | 435 (53.0) | 726 (66.4) | |
| T4b | 142 | 49 (6.0) | 93 (8.5) | |
| N status | <0.001 | |||
| N0 | 332 | 195 (23.8) | 137 (12.5) | |
| N1 | 308 | 175 (21.3) | 133 (12.2) | |
| N2 | 459 | 219 (26.7) | 240 (22.0) | |
| N3a | 494 | 160 (19.5) | 334 (30.6) | |
| N3b | 320 | 71 (8.7) | 249 (22.8) | |
| Stage (AJCC eighth edition) | <0.001 | |||
| IIA | 203 | 152 (18.5) | 51 (4.7) | |
| IIB | 357 | 214 (26.1) | 143 (13.1) | |
| IIIA | 548 | 241 (29.4) | 307 (28.1) | |
| IIIB | 454 | 135 (16.5) | 319 (29.2) | |
| IIIC | 351 | 78 (9.5) | 273 (25.0) | |
| Histological type | <0.001 | |||
| Differentiated | 710 | 397 (48.4) | 313 (28.6) | |
| Undifferentiated | 1203 | 423 (51.6) | 780 (71.4) | |
| Lymphatic invasion | 1263 | 417 (50.9) | 846 (77.4) | <0.001 |
| Vascular invasion | 336 | 66 (8.0) | 270 (24.7) | <0.001 |
| Surgical complication | 260 | 103 (12.6) | 157 (14.4) | 0.255 |
| Chemotherapy | 1401 | 592 (72.2) | 809 (74.0) | 0.373 |
Data are presented as numbers (percentages), unless otherwise stated. AJCC—American Joint Committee on Cancer; SD—standard deviation; LN—lymph node.