Table 2.
Association of studied variables with PD-L1 expression.
| Variables | PD-L1 Negative (50; 51%) | PD-L1 Positive (47; 49%) | p | |
|---|---|---|---|---|
| Age (years) | Median value (q1–q3; minimum–maximum) | 66 (54–78; 39–91) | 65(55–72; 34–88) | 0.509 |
| Ki67 | Median value (q1–q3; minimum–maximum) | 42 (30–70; 5–90) | 65 (50–80; 24–98) | 0.005 |
| Tumor size median value | Median value (q1–q3; minimum–maximum) | 2.1 (1.6–4.5; 0.9–10) | 2 (1.5–3; 0.9–5) | 0.411 |
| Histologic grade * | 2 | 15 (31) | 3 (6) | 0.005 |
| 3 | 34 (69) | 44 (94) | ||
| Histologic type | NOS | 37 (74) | 42 (89) | 0.092 |
| Other subtypes | 13 (26) | 5 (11) | ||
| Clinical stage ** | I | 20 (40) | 20 (43.5) | 0.795 |
| II | 21 (42) | 20 (43.5) | ||
| III | 9 (18) | 6 (13) | ||
| sTIL peripheral | Median value (q1–q3; minimum–maximum) | 15 (6.5–25; 1–35) | 30 (25–50; 0–80) | <0.001 |
| sTIL peripheral | ≤25% | 41 (82) | 19 (40) | <0.001 |
| >25% | 9 (18) | 28 (60) | ||
| sTIL central | Median value (q1–q3; minimum–maximum) | 10 (5–30; 1–35) | 25 (20–50; 2–85) | <0.001 |
| sTIL central | ≤20% | 43 (86) | 17 (36) | <0.001 |
| >20% | 7 (14) | 30 (64) | ||
| sTIL total | Median value (q1–q3; minimum–maximum) | 15 (9–20; 1–30) | 30 (20–45; 5–85) | <0.001 |
| sTIL total | ≤20% | 45 (90) | 17 (36) | <0.001 |
| >20% | 5 (10) | 30 (64) | ||
| itTIL | Median value (q1–q3; min–max) | 1 (1–2; 0–5) | 5 (1–10; 1–15) | <0.001 |
| itTIL | ≤2% | 42 (84) | 20 (43) | <0.001 |
| >2% | 8 (16) | 27 (57) | ||
| Primary lymphoid aggregates | No | 23 (46) | 8 (17) | 0.003 |
| Yes | 27 (54) | 39 (83) | ||
| Secondary lymphoid aggregates | No | 46 (92) | 37 (79) | 0.116 |
| Yes | 4 (8) | 10 (21) | ||
| NY-ESO-1 | 0 | 33 (66) | 27 (57) | 0.511 |
| ≥1 | 17 (34) | 20 (43) |
* One patient had a tumor of histological grade 1 and was excluded from analysis. ** One patient did not undergo lymphadenectomy and was excluded from the analysis.