Table 3.
Log-rank test and Cox regression univariate analysis for DFS in 97 TNBC.
| Variables | Log-Rank Test | Cox Regression Univariate Analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Average DFS (Months) (SE) | 95% CI | LR | p | RR | 95% CI | p | ||
| Ki67 (ROC analysis) | ≤55.5% | 45.1 (1.4) | 42–48 | 1.39 | 0.238 | 2.11 | 0.64–7 | 0.221 |
| >55.5% | 40 (2) | 36–44 | ||||||
| Histological grade * | 2 | 41.9 (3.2) | 35.7–48 | 0.404 | 0.525 | 0.698 | 0.189–2.6 | 0.590 |
| 3 | 41.8 (1.3) | 39–44 | ||||||
| Histological type | NOS | 41.7 (1.3) | 39–44 | 0.570 | 0.450 | 1.45 | 0.39–5.4 | 0.577 |
| Other subtypes | 41.6 (3.6) | 35–48 | ||||||
| Positive lymph nodes | No | 45 (1.1) | 43–48 | 6.4 | 0.011 | 4.1 | 1.3–12.8 | 0.017 |
| Yes | 36.4 (3.2) | 30–43 | ||||||
| sTIL peripheral by median value | ≤25% | 42.5 (1.7) | 39–46 | 0.957 | 0.328 | 0.547 | 0.15–2 | 0.366 |
| >25% | 42.7 (1.8) | 39–46.3 | ||||||
| sTIL central by median value | ≤20% | 42.5 (1.7) | 39–46 | 0.945 | 0.331 | 0.549 | 0.15–2 | 0.369 |
| >20% | 42.6 (1.9) | 39–46 | ||||||
| sTIL total by median value | ≤20% | 42.7 (1.6) | 39–46 | 0.677 | 0.411 | 0.603 | 0.163–2.23 | 0.448 |
| >20% | 42.4 (2) | 38–46 | ||||||
| Primary lymphoid aggregates | No | 37.7 (2.7) | 32–43 | 4.9 | 0.027 | 0.319 | 1–9.9 | 0.051 |
| Yes | 45.1 (1.3) | 42.6–46 | ||||||
| PD-L1 | Negative | 41.4 (2) | 37–45 | 2.97 | 0.085 | 0.351 | 0.095–1.3 | 0.117 |
| Positive | 43.3 (1.5) | 40–46 | ||||||
| NY-ESO-1 | 0% | 42.4 (1.7) | 39–46 | 0.841 | 0.359 | 0.518 | 0.14–1.9 | 0.324 |
| ≥1% | 43 (1.6) | 40–46 | ||||||
* One patient had a tumor of histological grade 1 and was excluded from analysis.