Table 3.

Top proteins identified in milk EVs that were identified by the Western blot technique.

Species	Protein	Functions	References
Human	Oleoyl-ACP Hydrolase	Metabolism	[107]
	Parathyroid Hormone-Related Protein	Endocrine Functions and Epithelial–Mesenchymal Interactions	[107]
	Myelin Protein Zero-Like Protein 1	Immunoglobulin Superfamily and a Receptor of Concanavalin A	[107]
	EH Domain-Containing Protein 3	Cholesterol and Sphingolipid Transport	[107]
	Heat Shock Cognate 70	Protein Homeostasis in Stressed and Non-Stressed Cells	[122]
	Heat Shock Protein 70
Cow	Butyrophilin, Xanthine Oxidase, Adipophilin, and Lactadherin	Milk Fat Globule Membrane (MFGM) Proteins	[108]
	MHC Class I	Immune Response
Pig	EGF, TGFβ-3, MSTN, CTGF, IGFBP-7, PDGFA, HTRA3, THBS1, and Lactoferrin	Acute Inflammatory Response, Complement Activation, Classical Pathway, B Cell-Mediated Immunity, Negative Regulation of Blood Coagulation, Activation of Immune Response, and Protein Maturation and Processing	[109]
Camel, cow, human, and pig	Tumor Susceptibility Gene 101 Protein (TSG101)	Vesicle trafficking	[75,107,108,123,124,125]