Table 1.

Inclusion/exclusion criteria and cardiovascular risk factors targets.

Inclusion Criteria	Exclusion Criteria
Consecutive adult patients with stable IHD and/or PAD: ∘ Stable IHD was defined as follows: ▪ (1) The history of previous myocardial infarction, or ▪ (2) Diagnosis of multivessel coronary disease with two major epicardial arteries having >50% stenosis, with symptoms or history of stable or unstable angina, or ▪ (3) Multivessel coronary disease revascularization, either percutaneous or surgical, within 1 to 10 years before inclusion. ▪ (4) In addition, patients should be ≥65 years or <65 years with revascularization of ≥2 major epicardial arteries, or with ≥2 additional risk factors (i.e., smoking, diabetes, eGFR < 60 mL/min/1.73 m2, heart failure or nonlacunar ischemic stroke). ∘ PAD was defined as: ▪ (1) Any revascularization of lower extremities, or ▪ (2) Previous vascular amputation of any part of lower extremities, or ▪ (3) Arterial stenosis ≥50%, or ▪ (4) History of intermittent claudication, or ▪ (5) An ankle–brachial index <0.9, or ▪ (6) Patients with carotid disease, including previous revascularization or arterial stenosis ≥50%. Patients should provide written informed consent	Patients hospitalized at inclusion Patients with a history of atrial fibrillation or other indication for anticoagulation
Cardiovascular risk factors targets
Blood pressure [17]	<140/90 mmHg <130/80 mmHg <120/70 mmHg
Lipids [18,19]	LDL cholesterol < 70 mg/dL LDL cholesterol < 55 mg/dL
Diabetes [20]	HbA1c < 7% and treatment with SGLT2i or GLP1-RA HbA1c < 6.5% and treatment with SGLT2i or GLP1-RA

eGFR: estimated glomerular filtration rate; SGLT2i: sodium-glucose cotransporter-2 inhibitors; GLP1-RA: glucagon-like peptide 1 receptor agonists.