Table 3.

Results of genome-wide significant variant from creatinine-based GWAS.

								eGFR (Continuous)			CTCAE-AKI (Binary)
Variant	Position a	Chr	Gene	Variant Type	Effect Allele	Non-Effect Allele	MAF	Coef. b	95% CI	p	OR c	95% CI	p
rs10663797	28,659,744	3	RBMS3	intronic	delAC	insAC	0.27	−0.10	−0.13–−0.06	2.72 × 10−8	5.69	2.54–12.74	2.33 × 10−5

Chr, chromosome; MAF, minor allele frequency; Coef., coefficient; CI, confidence interval; p, uncorrected p-value; OR, odds ratio. ^a Location on genome build GRCh37/hg19. ^b Coefficient below zero represents an increased risk of eGFR reduction when carrying the tested allele, and above zero indicates a decreased risk. ^c Odds ratio above 1 indicates an increased risk of eGFR reduction when carrying the tested allele, and below 1 indicates a decreased risk.