Table 4.
Replication results of variants found to be statistically significantly associated by Zazuli et al. (2021) [41]
| Gene | Variant | Data from Discovery Study Zazuli et al. (2021) [41] | Results Current Study (GWAS with eGFR Decline Phenotype) | Comparison | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect Allele | Beta | 95% CI | p | Effect Allele | Coef | 95% CI | p | Effect Allele | Non-Effect Allele | Direction Zazuli et al. a | Direction Current Study a | ||||
| TMEM225B | rs17161766 | A | −28.91 | −38.80 | −19.10 | 7.823 × 10−9 | NA | NA | NA | NA | NA | + | G | + | NA |
| - | chr7:98951080 | CTTAT | −27.19 | −36.50 | −17.90 | 9.485 × 10−9 | NA | NA | NA | NA | NA | + | C | + | NA |
| ARPC1A | rs199659233 | T | 28.65 | 18.70 | 38.60 | 1.473 × 10−8 | C | 0.008 | −0.115 | 0.130 | 0.899 | - | C | - | - |
| ARPC1A | rs556958738 | T | 28.65 | 18.70 | 38.60 | 1.473 × 10−8 | C | 0.008 | −0.115 | 0.131 | 0.899 | - | C | - | - |
| BACH2 | rs4388268 | A | −8.37 | −11.40 | −5.40 | 3.845 × 10−8 | A | 0.013 | −0.020 | 0.045 | 0.443 | + | G | + | + |
a Direction of effect, where (+) represents an increased risk of eGFR reduction when carrying the effect allele, and (-) a decreased risk. Chr, chromosome; BP, base-pair position on genomic build GRCh37/hg19; MAF, minor allele frequency; Coef., coefficient; 95% CI, 95% confidence interval; p, p-value; OR, odds ratio; NA, not available.