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. 2022 May 24;9(6):166. doi: 10.3390/jcdd9060166

Figure 2.

Figure 2

Incidence of CHD in the subgroups of the children, according to MTHFD1 genotype and maternal folate supplementation in early pregnancy. The highest incidence of CHD (91.7%) was seen for the MTHFD1 rs2236225 GG children whose mothers did not take any folate supplements. In contrast, the lowest incidences (~44%) were seen for the children of mothers who started folate intake early, irrespective of the MTHFD1 genotype, and in the MTHFD1 AG/AA children of mothers who started folate intake later than 3 weeks post conception.