Table 3.
Multinomial logistic regression models of maternal and children`s selected genetic risk factors in control and CHD sub-groups (septal, left ventricular outflow tract obstruction [LVOTO], and conotruncal). LVOTO, left ventricular outflow tract obstruction; OR, odds ratio; CI, confidence interval; SLC19A1, solute-carrier family 19; FPGS, folypolyglutamyl synthase; GNMT, glycine N-methyltransferase; DNMT3B, DNA (cytosine-5-)-methyltransferase 3 beta; MTHFD1, trifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase/synthase; MTRR, 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase.
| Variable | Control vs. Septal | Control vs. LVOTO | Control vs. Conotruncal | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | p adj‡ | OR (95% CI) | p adj‡ | OR (95% CI) | p adj‡ | |
| Child genotype SLC19A1 rs1051266 GG † vs. AG or AA | 0.6 (0.3–1.3) | 0.178 | 0.6 (0.2–1.7) | 0.358 | 1.7 (0.5–6.0) | 0.389 |
| Maternal genotype FPGS rs1544105 CC or CT † vs. TT | 0.9 (0.4–2.0) | 0.775 | 1.9 (0.7–5.6) | 0.221 | 0.3 (0.05–1.5) | 0.139 |
| Maternal genotype GNMT rs10948059 CC or CT † vs. TT | 1.5 (0.7–3.2) | 0.316 | 0.8 (0.3–2.7) | 0.745 | 1.6 (0.5–4.9) | 0.402 |
| Maternal genotype DNMT3B rs2424913 CC † vs. CT or TT | 0.5 (0.3–1.1) | 0.090 | 1.3 (0.4–3.8) | 0.649 | 1.3 (0.4–4.0) | 0.686 |
| Child genotype MTHFD1 rs2236225 GG † vs. AG or AA | 0.8 (0.4–1.7) | 0.543 | 0.9 (0.3–2.6) | 0.895 | 0.2 (0.08–0.7) | 0.007 |
| Child genotype MTHFR 677 CC/1298 AA † vs. at least one mutated allele | 0.8 (0.3–2.5) | 0.761 | 0.7 (0.2–3.0) | 0.647 | 0.4 (0.1–1.5) | 0.190 |
| Maternal genotype MTRR rs1801394 AA or AG † vs. GG | 1.1 (0.5–2.2) | 0.882 | 1.3 (0.5–3.4) | 0.562 | 0.5 (0.2–1.6) | 0.231 |
| Child genotype MTRR rs1801394 AA † vs. AG or GG | 0.9 (0.3–2.4) | 0.838 | 0.7 (0.2–2.8) | 0.660 | 0.2 (0.08–0.7) | 0.013 |
| Number of mutated alleles in mother-child pairs | 1.0 (0.9–1.1) | 0.695 | 1.0 (0.9–1.2) | 0.941 | 0.9 (0.7–1.0) | 0.095 |
† Reference category. ‡ All genetic risk factors were adjusted for environmental risk factors listed in Table 2. Odds ratio (OR), 95% confidence interval, and adjusted p values were calculated in multinomial logistic regression models for mothers and children separately. Only variables with unadjusted p values < 0.250 were included in the multinomial logistic regression models and adjusted for co-variables.