Table 4.
Likelihood ratio test best hits in the family triads. CHDs, congenital heart defects; LVOTO, left ventricular outflow tract obstruction; FPGS, folypolyglutamyl synthase; SLC19A1, solute carrier family 19 member 1; MTHFD1, trifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase/synthase.
| CHD Type | Gene | Single Nucleotide Polymorphism | Model | Number of Triads | Likelihood Ratio | p (α = 0.05) |
|---|---|---|---|---|---|---|
| CHD total | MTHFD1 | rs2236225 | Recessive | 44 | 5.429 | 0.020 |
| LVOTO | FPGS | rs1544105 | Dominant | 7 | 4.861 | 0.027 |
| Conotruncal | SLC19A1 | rs1051266 | Dominant | 4 | 4.052 | 0.044 |
| MTHFD1 | rs2236225 | Recessive | 4 | 5.895 | 0.015 |