Table 4.
Echocardiogram parameters during the third trimester.
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | ||
|---|---|---|---|---|---|---|---|
| Gestational Age (wk) | 37 | 36 | 29 | 34 | 37 | 33 | 34 |
| RV Enlargement | Moderate | Severe | Mild | Moderate | None | Mild | Mild |
| RV dysfunction | Mild | Moderate | None | Mild | None | Mild | Mild |
| TAPSE (cm) | 1.8 | 1.7 | 2.0 | 1.8 | 2.9 | 1.8 | 1.7 |
| TR | Mild | Moderate | None | None | Mild | Mild | Mild |
| Septal Flattening | Moderate | Severe | None | Mild | None | Moderate | None |
| RVOT pulse wave Doppler notch | None | Late | None | None | None | Mid | None |
| Pericardial effusion | None | None | None | Mild | None | None | None |
| RVSP (mmHg) | 65 | 75 | N/A | 50 | 40 | 48 | 53 |
| Medications at the time of the echocardiogram | Sildenafil 60 mg TID and inhaled treprostinil 12 inh/q6h | SC treprostinil 40 ng/kg/min and Sildenafil 40 mg TID | IV treprostinil 51 ng/kg/min and sildenafil 60 mg TID | Tadalafil 40 mg daily | Inhaled treprostinil 9 inh/q6h and sildenafil 60 mg PO TID | Tadalafil 40 mg daily and inhaled treprostinil 12 inh/q6h | |
N/A = not available due to lack of TR; RVOT = right ventricle outflow tract; RVSP = right ventricular systolic pressure; wk = weeks; SC = subcutaneous; TAPSE = triscupid annular plane systolic excursion; TR = Tricuspid regurgitation.