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. 2022 May 25;12(6):860. doi: 10.3390/jpm12060860

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Experimental timelines: (A) Animals were divided into exercise and sedentary groups. Exercise animals received 6 weeks of exercise, while sedentary animals remained in their home cages. All animals underwent PET scans after the conclusion of 6 weeks. (B) Timeline of PET procedure: Animals were injected with [18F]-Fluorodeoxyglucose (FDG) via intraperitoneal injection. They were returned to their home cages for a 30-min uptake period. At the end of the uptake period, animals were anesthetized and placed in the bed of the PET R4 tomograph machine. PET scans lasted 30 min. After the scan, animals were recovered and returned to their home cages.