Table 1. A chronologically-ordered literature review of reported cases of primary vaginal adenocarcinoma of intestinal-type.

CEA: Carcinoembryonic antigen, EMA: Epithelial membrane antigen, CK20: Cytokeratin 20, CK7: Cytokeratin 7, ER: Estrogen receptor, PR: Progesterone receptor, CDX2: Caudal-type homeobox 2, SATB2: Special AT-rich sequence-binding protein 2, TTF-1: Thyroid transcription factor 1, HPV: Human papillomavirus, MMR proteins: Mismatch repair proteins

Authors	Patient Age (years)	Tumor Size (cm)	Tumor Site	Immunohistochemical & Other Stains	DES exposure
Fukushima et al. [14] (1986)	32 years	3 x 3 x 2 cm	Distal third of the vaginal wall	Neuroendocrine markers were expressed due to mixed components	Unknown
Fox et al. [6] (1988)	35 years	5 x 2 cm	Left lateral and anterior vaginal wall	Unknown	Unknown
Yaghsezian et al. [15] (1992)	52 years	1 cm	Posterior distal vaginal wall	Unknown	Not present
Nagar et al. [16] (1999)	36 years	Depth only: 0.1 cm	Upper anterior vaginal wall	Not reported	Not present
Heller et al. case 1 [17] (2000)	55 years	7 x 4 cm	Anterior lower vaginal wall	CEA+, EMA+	Not present
Heller et al. case 2 [17] (2000)	52 years	2.5 cm	Anterior lower vaginal wall	CEA+, EMA+	Not present
Mudhar et al. [18] (2001)	56 years	1 cm	Distal posterior vaginal wall	CEA+, CK20+, CK7-	Not present
Tjalma and Colpaert et al. [19] (2006)	55 years	4.5 x 4 x 2.7 cm	Anterior lower and posterior vaginal walls	CEA+, CK20+, CK7+, ER-, PR-	Unknown
Ditto et al. [1] (2007)	53 years	1 x 2 cm	Distal posterior vaginal wall	CK20+, CDX2+, CK7-	Not present
Driss et al. [20] (2007)	70 years	4 cm	Anterior lower and middle vaginal walls	CEA+, CK20+, EMA+, CK7-	Not present
van Wessel et al. [21] (2013)	68 years	1 x 1.3 cm	Posterior wall of vaginal introitus	CEA+, CK20+, CK7+	Not present
Staats et al. [22] 10 cases (2014)	Range: 36 to 86 years	Range: 0.8 to 1.5 cm	Variable	CEA+, CK20+, CDX2+, CK (+/-), ER-, PR-	Not present in most cases, few could not be excluded
Tatsumi et al. [3] (2015)	64 years	2 cm	Posterior vaginal wall	CK20+, CDX2+, CK7+ (focal), ER-	Present
Broggi et al. [23] (2018)	51 years	2 cm	Posterior wall of vaginal introitus	CEA+, CK20+, CDX2+, CK7+ (focal), ER-, PR-	Not reported
Ugwu et al. [9] (2019)	40 years	6 x 3 cm	Posterior wall of the lower-third of the vagina with extension to the introitus	Not reported	Not reported
Current case (2022)	62 years	Bilobed components: 1.8 cm, and 2.3 cm	Bilobed components: Middle one-third of the vagina, and lower one-third of the vagina (respective to size)	CEA+, CK20+, CDX2+, EMA+ (focal), SATB2+, TTF-1+ (patchy) CK7-, ER-, PR-, p16-, GATA3- In-situ hybridization for high-risk HPV – MMR proteins -	Not present