Figure 11.
Impact of diet and adipokines on cervical resistance in 22-day pregnant rats. Cervical resistance was measured in an isolated organ bath applying a stretching test. The high fat high sugar diet (HFHSD) itself reduced cervical resistance as compared with the standard diet (SD) in the control group. Kisspeptin (10−7 M) and adiponectin (10−9 M) reduced cervical resistance in SD samples, while leptin (10−8 M) was ineffective. HFHSD ceased the cervical resistance reducing effects of kisspeptin and adiponectin, but leptin further decreased resistance *: p < 0.05; **: p < 0.01; ***: p < 0.001.