Figure 1.

Overview of imputing gene expression from genotype. The PrediXcan models (round-cornered box) were downloaded from https://predictdb.org (accessed on 21 April 2021). They were developed for a number of tissues using the matched genotype and gene expression datasets compiled by the GTEx consortium. A given gene’s expression value was linearly modeled from the genotypes of neighboring single-nucleotide proteins (SNPs), which was selected through elastic net. By applying the linear regression weights to our genotype data (upper right), we were able to impute the gene expression in our tissue of interest (lower right).