Table 2.

Most frequent clinical manifestations in IE in the general population [29,30,50].

Clinical Presentation of IE
Signs	Symptoms
New-onset heart murmur (50–85%)	Fever (90%)
Congestive heart failure (30%)	Chills
New conduction disturbances (2%)	Malaise
Disturbances in CNS (stroke, meningitis…) (14%)	Dyspnea
Peripheral septic abscesses or emboli	Anorexia
(renal, splenic, vertebral…) (5%)	Weight loss
Septic pulmonary emboli (6%)	Generalized weakness
Fever or sepsis of unknown origin	Back pain
Splinter hemorrhages (8%)
Roth’s spots (8%)
Acute kidney failure (23%)
Anemia (Hb <10 g/dL) (20%)