Appendix 1—table 1. Anatomical parameters, early markers of cardiac hypertrophy and fibrosis, and echocardiographic parameters were measured in wild-type (WT) mice after subjected to TAC versus sham-operated controls (n=6–7/group).
Appendix 1—table 1—source data 1.
elife-74519-app1-table1-data1.xls (52.5KB, xls)
| 2 d | 1 w | 2 w | 4 w | |||||
|---|---|---|---|---|---|---|---|---|
| Sham | TAC | Sham | TAC | Sham | TAC | Sham | TAC | |
| Anatomical parameter | ||||||||
| n | 7 | 7 | 7 | 7 | 7 | 7 | 6 | 6 |
| HW/BW | 4.4±0.1 | 4.5±0.1 | 5.1±0.2 | 7.3±0.7*** | 4.5±0.3 | 7.1±1.1*** | 4.5±0.3 | 7.1±0.8** |
| HW/TL | 6.0±0.2 | 6.0±0.1 | 6.7±0.6 | 8.4±0.6*** | 6.0±0.3 | 9.3±1.4*** | 6.3±0.5 | 9.7±1.6*** |
| Early markers of cardiac hypertrophy and fibrosis | ||||||||
| n | 6 | 6 | 6 | 6 | 6 | 6 | 7 | 7 |
| ANP | 1.0±0.3 | 1.1±0.2 | 1.0±0.5 | 9.1±3.9*** | 1.0±0.4 | 28.1±11.5*** | 1.0±0.2 | 7.3±1.9*** |
| BNP | 1.0±0.2 | 0.7±0.1 | 1.0±0.4 | 11.5±2.0*** | 1.0±0.3 | 5.2±1.1*** | 1.0±0.4 | 2.7±0.4** |
| Collagenase-1 | 1.0±0.4 | 1.4±0.7 | 1.0±0.4 | 1.1±0.3 | 1.0±1.3 | 1.0±0.7 | 1.0±0.2 | 6.8±2.5** |
| Collagenase-3 | 1.0±0.2 | 1.0±0.5 | 1.0±0.4 | 1.30±0.25 | 1.0±1.1 | 2.5±2.1 | 1.0±0.3 | 3.8±1.2** |
| Echocardiographic parameters | ||||||||
| n | 7 | 7 | 7 | 7 | 7 | 7 | 6 | 6 |
| EF (%) | 66.4±7.2 | 65.0±8.9 | 71.0±5.9 | 68.7±3.5 | 75.7±4.4 | 60.2±3.9*** | 68.8±3.3 | 52.8±10.6** |
| FS (%) | 36.0±5.1 | 34.2±6.7 | 39.8±6.6 | 36.1±3.5 | 43.4±4.0 | 31.3±2.6*** | 37.6±2.7 | 26.9±6.5** |
HW/BW: heart weight to body weight ratio, HW/TL: heart weight to tibia length ratio, EF: ejection fraction, FS: fractional shortening, Data represent means ± SD, **P<0.01, ***P<0.001, compared between sham- and TAC operated groups.