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. 2022 Mar 15;18(5):2046960. doi: 10.1080/21645515.2022.2046960

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© 2022 Merck & Co., Inc. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 6. — Longitudinal geometric mean titers stratified by baseline flavivirus status.

The geometric mean titer (GMT) of neutralizing antibody is shown over time (Study Days 1, 28, 56, 180, 208, 360, and 530). Data is displayed by dengue virus type stratified by the baseline flavivirus experienced subgroup (Panel A) and by flavivirus naïve subgroup (Panel B) as measured by virus neutralization reduction test (VRNT₆₀). Error bars represent the 95% confidence intervals. Per protocol population is shown. The dotted dashed gray line on each graph represents ½ LLOQ. TV003=V181, TV003 formulation. TV005=V181, TV005 formulation.