Table 2.
Summary of Forced Swim Test Immobility Time (Seconds) with Vehicle (Veh) or Fluoxetine (Fluo) for Control and Perinatal Cannabinoid Exposure Adult Progenies (THC, CBD, THC+CBD)
| Sex | Age | Control |
THC |
CBD |
THC+CBD |
Adjusted p-values for Veh vs. Fluo |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Veh | Fluo | Veh | Fluo | Veh | Fluo | Veh | Fluo | Ctrl | THC | CBD | THC+CBD | ||
| Males | P100–120 | 139.05±12.058 (n=20) | 98.762±9.37 (n=21) | 141.41±12.06 (n=17) | 130.78±12.67 (n=18) | 116.93±16.59 (n=15) | 103.53±11.72 (n=15) | 129.23±13.02 (n=13) | 85.54±18.29 (n=13) | 0.032505 | 0.742982 | 0.742982 | 0.241968 |
| Females | P100–120 | 142.72±8.34 (n=29) | 77.52±10.60 (n=23) | 129.63±15.60 (n=16) | 107.25±18.02 (n=16) | 148.47±14.06 (n=19) | 142.35±13.78 (n=20) | 110.64±12.556 (14) | 75.65±15.32 (n=17) | 0.000139 | 0.660578 | 0.660578 | 0.255716 |
| Both sexes | P100–120 | 141.22±6.90 (n=49) | 87.66±7.22 (n=44) | 135.70±9.69 (n=33) | 119.71±10.84 (n=34) | 134.56±10.92 (n=34 | 125.71±9.78 (n=35) | 119.59±9.05 (n=27) | 79.93±11.59 (n=30) | 0.000003 | 0.616405 | 0.616405 | 0.050077 |
The distribution of data residuals was non-normal. Multiple Mann–Whitney tests corrected by the Holm–Sidak method for multiple comparisons were employed for statistical comparisons. There was no sex-dependent difference for mice treated with vehicle or fluoxetine and thus data from both sexes were merged for statistical comparisons.