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. 2022 Jun 6;7(3):294–303. doi: 10.1089/can.2021.0027

FIG. 2.

FIG. 2.

CBG did not disrupt acquisition, consolidation, or reconsolidation of contextual fear memory. (a) Acquisition: mice were administered 1, 10, or 30 mg/kg of CBG or vehicle before contextual fear conditioning. Retrieval was measured 24 h later. n=10 per group. (b) Consolidation: mice were fear conditioned and immediately administered 1, 10, or 30 mg/kg of CBG. Retrieval was measured 24 h later. n=8–10 per group. (c) Reconsolidation: mice were fear conditioned and fear memory was reactivated in the fear conditioning context 24 h later. Mice were immediately administered 3, 10, 30, or 60 mg/kg of CBG after reactivation. Retrieval was measured 24 h later. n=8–18 per group. Data are expressed as mean+SEM. *p<0.05, ****p<0.0001 and indicates significant differences when compared to the NS-VEH group (Mann–Whitney U test or unpaired t-test). ns, not significant compared to S-VEH (one-way ANOVA). NS-VEH, non-shock-vehicle; S-VEH, shock-vehicle; S-CBG1, shock-cannabigerol 1 mg/kg; S-CBG3, shock-cannabigerol 3 mg/kg; S-CBG10, shock-cannabigerol 10 mg/kg; S-CBG30, shock-cannabigerol 30 mg/kg; S-CBG60, shock-cannabigerol 60 mg/kg.