FIG. 3.

CBG did not disrupt trauma-induced generalized anxiety. (a) Experimental protocol: mice were shocked and 24 h later administered vehicle, or 10 or 30 mg/kg of CBG. They were then placed into the light/dark box to test for generalized anxiety. The control NS-VEH group was not fear conditioned and treated with vehicle. (b) Total distance travelled in the light box. (c) Percent of total time mice spent in the light box. (d) Number of total entries into the dark box. (e) Latency to the first entry into the dark box. Data are expressed as mean+SEM (n=19–20 per group). ns, not significant, **p<0.01, ***p<0.001, ****p<0.0001. Bars indicate significant differences when compared to the leftmost group, that is, the NS-VEH group (Dunn's post-hoc tests) or the S-VEH group (one-way ANOVA or Kruskal–Wallis test). NS-VEH, non-shock-vehicle; S-VEH, shock-vehicle; S-CBG10, shock-cannabigerol 10 mg/kg; S-CBG30, shock-cannabigerol 30 mg/kg.