Table 3.
All genera meeting FDR Significance for an ordinal test of differential CLR-transformed relative abundances between healthy controls, Asym/UAS, and SS/SLE groups
| Family | Genus | Healthy Controls | Asym/UAS | SS/SLE | 3 Group Ordinal1 | 3 Group Ordinal1 FDR | Control vs. anti-Ro |
|---|---|---|---|---|---|---|---|
| Actinomycetaceae | Actinomyces | 0.0011 ± 0.0021 | 0.0006 ± 0.0011 | 0.0006 ± 0.0009 | 1.62E-03 | 2.66E-02 | 1.26E-03 |
| Bacteroidaceae | Bacteroides2 | 0.0682 ± 0.0968 | 0.1976 ± 0.1600 | 0.2265 ± 0.2169 | 7.38E-07 | 9.37E-05 | 4.03E-09 |
| Bifidobacteriaceae | Bifidobacterium2 | 0.0997 ± 0.0998 | 0.0261 ± 0.0559 | 0.0335 ± 0.0596 | 1.20E-05 | 7.64E-04 | 7.99E-10 |
| Lachnospiraceae | Blautia2 | 0.134 ± 0.0593 | 0.0773 ± 0.0824 | 0.1064 ± 0.1083 | 6.55E-04 | 2.08E-02 | 7.73E-08 |
| Lachnospiraceae | Coprococcus_1 | 0.0034 ± 0.0036 | 0.0029 ± 0.0044 | 0.0023 ± 0.0034 | 1.47E-03 | 2.66E-02 | 1.16E-02 |
| Lachnospiraceae | Coprococcus_32 | 0.0107 ± 0.0099 | 0.0074 ± 0.0163 | 0.0064 ± 0.0101 | 3.91E-03 | 4.13E-02 | 3.85E-03 |
| Lachnospiraceae | Lachnoclostridium | 0.0058 ± 0.0072 | 0.0113 ± 0.0171 | 0.0198 ± 0.0284 | 9.12E-05 | 3.86E-03 | 9.34E-04 |
| Peptostreptococcaceae | Romboutsia | 0.0247 ± 0.0444 | 0.0233 ± 0.0446 | 0.017 ± 0.037 | 1.67E-03 | 2.66E-02 | 2.12E-03 |
| Ruminococcaceae | Flavonifractor | 0.0007 ± 0.0011 | 0.0019 ± 0.0032 | 0.0036 ± 0.0066 | 1.20E-03 | 2.66E-02 | 3.33E-03 |
| Ruminococcaceae | Intestinimonas2 | 0.0004 ± 0.0011 | 0.0012 ± 0.0019 | 0.0015 ± 0.0019 | 3.62E-03 | 4.13E-02 | 1.42E-03 |
| Ruminococcaceae | Oscillibacter2 | 0.001 ± 0.0026 | 0.0036 ± 0.0042 | 0.0043 ± 0.0073 | 3.19E-03 | 4.05E-02 | 3.19E-06 |
| Ruminococcaceae | Oscillospira2 | 0 ± 0 | 0.0005 ± 0.0013 | 0.0006 ± 0.0018 | 2.30E-03 | 3.25E-02 | 2.38E-03 |
| Ruminococcaceae | Ruminiclostridium_9 | 0.0012 ± 0.0015 | 0.0014 ± 0.0013 | 0.0029 ± 0.0035 | 4.42E-03 | 4.31E-02 | 3.04E-02 |
1An ordinal, three-group contrast within a GLM was used to test for differences across healthy controls, Asym/UAS, and SS/SLE, assuming an ordering in clinical severity (HC<Asym/UAS<SS/SLE). 2A three-group contrast within a GLM was also used to test for differences between healthy controls, Asym/UAS, and SS/SLE without assuming an ordering in clinical severity. Genera for which the non-ordinal FDR-adjusted p-value was more significant than the FDR-adjusted ordinal p-value included Bacteroides (1.07E-06), Bifidobacterium (7.51E-07), Blautia (1.83E-05), Coprococcus_3 (4.08E-02), Intestinimonas (2.83E-02), Oscillospira (3.00E-02), and Oscillibacter (5.12E-04). “Anti-Ro” in the rightmost column indicates Asym/UAS and SS/SLE combined.