Table 4.
Significant HLA x genus interactions for genera that met FDR-adjusted significance in the differential abundance analysis
| HLA Allele | Family | Genus | Interaction P-value | Odds Ratio (95% CI) | Overall Mean Abundance |
|---|---|---|---|---|---|
| DRB1*03:01 | Ruminococcaceae | Intestinimonas | 0.026 | 1.66 (1.06–2.58) | 0.001463 |
| DRB1*15:01 | Lachnospiraceae | Lachnospiraceae_UCG-010 | 0.004 | 0.48 (0.29–0.79) | 0.001095 |
| DRB1*15:01 | Ruminococcaceae | Oscillibacter | 0.033 | 0.60 (0.37–0.96) | 0.004236 |
| DRB1*15:01 | Ruminococcaceae | Intestinimonas | 0.044 | 0.63 (0.40–0.99) | 0.001463 |
| DQB1*02:01 | Ruminococcaceae | Ruminiclostridium_9 | 0.020 | 1.85 (1.10–3.11) | 0.002591 |
| DQB1*02:01 | Ruminococcaceae | Intestinimonas | 0.033 | 1.58 (1.04–2.41) | 0.001463 |
| DQB1*06:02 | Lachnospiraceae | Lachnospiraceae_UCG-010 | 0.006 | 0.52 (0.33–0.83) | 0.001095 |
| DQB1*06:02 | Ruminococcaceae | Oscillibacter | 0.011 | 0.57 (0.36–0.88) | 0.004236 |
| DQB1*06:02 | Ruminococcaceae | Intestinimonas | 0.022 | 0.60 (0.39–0.93) | 0.001463 |
| DQB1*06:02 | Lachnospiraceae | Lachnospiraceae_NK4A136 group | 0.034 | 0.65 (0.44–0.97) | 0.012772 |
| DQB1*06:02 | Ruminococcaceae | Anaerotruncus | 0.047 | 0.61 (0.38–0.99) | 0.001864 |