Table 9.

Possible binding interactions of compound 6e into Aurora A active site.

Binding Motif	Amino Acid *	Binding Interaction	Distance (Å)
Central motif (quinazoline)
Phenyl	Ala 160 Val 147 Leu 263	Hydrophobic Hydrophobic Hydrophobic	- - -
Pyrimidine	Leu 139 Val 147 Leu 263	Hydrophobic Hydrophobic Hydrophobic	- - -
F	Glu 211 Tyr 212 Ala 213	Halogen Halogen Halogen	3.52 2.61 2.49
Terminal motif
Phenyl	Leu 139	Hydrophobic	-
Br	Leu 139 Tyr 212 Pro 214	Halogen Halogen Halogen	- - 3.27

* Ala, alanine; Val, valine; Leu, leucine; Glu, glutamine; Tyr, tyrosine; Pro, proline.