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. 2022 Mar 29;18(5):2048622. doi: 10.1080/21645515.2022.2048622

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Figure 4. — Dynamics of body weight changes following SARS-CoV-2 infection of HIS-DRAGA mice.

(a) Daily monitoring for body weights of HIS-DRAGA male mouse #M1 (dark circles) infected with SARS-CoV-2 virus (10⁴ pfu) and 2 HIS-DRAGA female mice #F1 and #F2 (gray circles) infected with 10⁴ pfu and 2.8x10³ pfu, respectively (pilot infection experiment). (b) Daily monitoring for body weights of 3 HIS-DRAGA female mice (#F11 - #F13, open circles) and three male mice (#M2 - #M4, dark circles) infected with SARS-CoV-2 virus (10³ pfu/mouse). (c) Viral RNA copies in the lungs of mice from panel B measured as described in the Materials and Methods. (d) Daily monitoring of body weights of 2 HIS-DRAGA female mice (#F3 and #F4) that recovered from infection after challenge with SARS-CoV-2 virus (10³ pfu/mouse). (e) Daily monitoring of body weights of six HIS-DRAGA female mice (#F5 - #F10, 6/8 mice, 75%) that did not recover from infection after challenge with SARS-CoV-2 (10³ pfu/mouse).