Figure 4.

BiP treatment increases the number of minerals in the atherosclerotic plaque of ApoE^−/− mice. Number of the mineral per tissue in (A) male and (B) female mice; (C) comparison of total plaque calcification between male and female mice. * p < 0.05, ** p ≤ 0.01, *** p ≤ 0.001 and **** p ≤ 0.0001, two-way ANOVA with Tukey’s post-hoc test was used for comparison between multiple groups, and Student’s t-test was used for comparison between two groups. “ns” stands for not significant.