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. 2022 May 25;9(6):168. doi: 10.3390/jcdd9060168

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bone remodeling positively correlated with duration of BiP treatment. (A) Reconstruction of femoral bone microstructure for the different treated and untreated groups; Panel (B) is the bone volume fraction (bone volume/total volume) for the cortical and trabecular regions; Panel (C) is the bone thickness for the cortical and trabecular regions. * p < 0.05, ** p ≤ 0.01, *** p ≤ 0.001, and **** p ≤ 0.0001, two-way ANOVA with Tukey’s post-hoc test. Male mice (●) and female mice (■). “ns” stands for not significant.