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Immune-related adverse event (IrAE) group included eight patients who developed irAEs after 3 weeks. (a) Changes in proportions of circulating B cells are represented as the percentage of total peripheral blood mononuclear cells (PBMCs). (b) Changes in proportions of CD21lo B cells. All data represent the mean ± standard error of mean (SEM). * p < 0.05 by two-tailed Wilcoxon signed-rank test.
