Table 1.

Comparison of four therapeutic apheresis techniques.

	PE	DFPP	IAS	LDL-A
Selectivity	Non-selective	Semi-selective	Semi-selective	Semi-selective
Plasma processing volume	1–1.5 times (very limited)	1–2 times (limited)	2–3 times (unlimited theoretically)	2–3 times (unlimited theoretically)
Substitution solution	Crystalloid/colloid (HSA or FFP)	Little HSA or saline	No substitution solution	No substitution solution
Removal of protein	Remove all plasma components	Remove macromolecules	Remove pathogenic factors selectively (predominantly immunoglobulins)	Remove LDL and other lipoproteins

PE: Plasma exchange; DFPP: double-filtration plasmapheresis; IAS: immunosorption; LDL-A: low-density lipoprotein apheresis; HSA: human serum albumin; FFP: fresh frozen plasma.