Table 2.

Indications for therapeutic apheresis in diseases involved kidney and their pathogenic factors.

Medical disciplines	Diseases	Pathogenic factors
Primary kidney diseases	FSGS	Circulatory permeability factors
	MN	PLA2R Ab and THSD7A Ab
	Anti-GBM glomerulonephritis (Goodpasture’s syndrome)	Anti-GBM Ab
Secondary kidney diseases	ANCA-associated vessel vasculitis	Anti-MPO or anti-PR3 Ab
	TTP	ADAMTS-13 Ab, ICs
	aHUS	Complement regulatory components or autoantibodies
	SLE	Anti-dsDNA Ab, anti-nuclear Ab, ICs
KT	ABO-incompatible KT	Blood group isoagglutinins
	HLA-incompatible KT	HLA and non-HLA alloantibodies
	Ab-mediated allograft rejection	HLA and non-HLA alloantibodies

FSGS: Focal segmental glomerulosclerosis; MN: membranous nephropathy; PLA2R: M-type phospholipase A2 receptor; THSD7A: thrombospondin type 1 domain-containing protein 7 A, Ab: antibody; GBM: glomerular basement membrane; ANCA: antineutrophil cytoplasmic antibodies; MPO: myeloperoxidase; PR3: proteinase 3; TTP: thrombotic thrombocytopenic purpura; ADAMTS-13: a disintegrin-like and metalloprotease with thrombospondin type 1 motifs-13; ICs: immune complexes; aHUS: atypical hemolytic uremic syndrome; SLE: systemic lupus erythematosus; KT: kidney transplantation; HLA: anti-human leukocyte antigen.