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. 2022 Jun 14;37(1):1694–1703. doi: 10.1080/14756366.2022.2081164

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — (A) Structure of the human BRDs of transcriptional coactivator CREB-binding protein CREBBP (PDB: 5NU3). The KAc binding site is blocked by the inhibitor XDM-CBP (shown in yellow)²⁷^,⁵⁸. (B) Phylogenetic tree of the human BRDs family. The green branches represent proteins such as BRD2, BRD3, BRD4, etc. The purple branches represent proteins such as BRD1, BRD7, and BRD9⁵⁹.