Table 1.

In vitro COX-1 and COX-2 inhibitory IC₅₀ values and COX SI values of the target compounds (5a-o).

Compound ID	IC50 µM		SIc COX-1/COX-2
	COX-1a	COX-2b
Celecoxib	14.7 ± 0.06	0.05 ± 0.0003	294
Rofecoxib	14.5 ± 0.06	0.03 ± 0.0006	483.3
Indomethacine	0.1 ± 0.003	0.08 ± 0.0003	1.25
Diclofenac sodium	3.8 ± 0.03	0.84 ± 0.003	4.5
5a	9.6 ± 0.06	0.11 ± 0.0003	87.3
5b	12.2 ± 0.06	0.07 ± 0.0005	187.7
5c	11.2 ± 0.08	0.08 ± 0.0003	145.5
5d	10.6 ± 0.08	0.09 ± 0.001	116.5
5e	8.3 ± 0.06	0.12 ± 0.003	69.2
5f	9.7 ± 0.06	0.11 ± 0.003	88.2
5g	10.5 ± 0.08	0.10 ± 0.0003	109.4
5h	8.2 ± 0.12	0.14 ± 0.000	58.6
5i	11.2 ± 0.11	0.08 ± 0.0008	136.6
5j	12.2 ± 0.06	0.05 ± 0.0005	239.2
5k	10.3 ± 0.08	0.09 ± 0.0003	111.9
5l	10.2 ± 0.08	0.08 ± 0.001	134.2
5m	9.9 ± 0.00	0.10 ± 0.0008	102.1
5n	10.6 ± 0.08	0.07 ± 0.0005	153.6
5o	12.9 ± 0.05	0.06 ± 0.0008	211.5

^a,bConcentration of the compound that causes 50% inhibition of enzymatic activity of cyclooxygenase 1 and 2 (COX-1 and COX-2), respectively and all 

values are expressed as Mean ± SEM of triplicate determinations.

^cCOX-2 selectivity index: (COX-1 _IC50/COX-2 _IC50).