Table 2.

Effects of the target compounds 5 b, 5j, 5n and 5o on carrageenan-induced paw edoema in mice (mm), their percentage anti-inflammatory activity and their ED₅₀ values (µmol/kg) (95% confidence level).

Compound NO.a	Thickness of edoema (mm)b					ED50 ( µmol /kg) (95% confidence level)
	0h	2h	4h	6h	8h
Control (carrageenan)	0.69 ± 0.004	0.95 ± 0.02	1.44 ± 0.03	2.05 ± 0.03	2.03 ± 0.01
Celecoxib	0.62 ± 0.01	0.89 ± 0.01c	0.79 ± 0.01c	0.73 ± 0.03c	0.67 ± 0.02c	13.07 (10.65 − 15.93)
		(6.32%)d	(45.14%)	(64.39%)	(70.87%)
Diclofenac	0.69 ± 0.004	1.06 ± 0.03c	0.89 ± 0.01c	0.80 ± 0.01c	0.71 ± 0.01c	11.46 (9.98 − 13.16)
		(-11.58%)	(38.19%)	(60.98%)	(69.13%)
5 b	0.68 ± 0.01	0.95 ± 0.04	1.19 ± 0.01	1.11 ± 0.01	1.01 ± 0.02	18.69 (16.41 − 21.10)
		(0%)	(20.83%)	(45.85%)	(56.09%)
5j	0.67 ± 0.02	0.80 ± 0.01c	0.70 ± 0.01c	0.60 ± 0.01c	0.53 ± 0.01c	10.94 (9.48 − 12.65)
		(15.79%)	(51.39%)	(70.73%)	(88.50%)
5n	0.66 ± 0.004	1.03 ± 0.03	1.29 ± 0.01	0.99 ± 0.05	0.90 ± 0.01	14.39 (11.69 − 17.53)
		(-8.42%)	(10.42%)	(51.71%)	(60.87%)
5o	0.65 ± 0.004	0.89 ± 0.01c	0.82 ± 0.02c	0.75 ± 0.02c	0.64 ± 0.02c	13.27 (11.81 − 14.88)
		(6.32%)	(43.06%)	(63.41%)	(72.17%)

Data were analysed by one-way ANOVA followed by Tukey’s Karmer post hoc test for multiple comparisons.

^aDose level for all compounds, po: 10 µmol/kg b.wt.

^bValues are expressed as Mean ± SEM (number of animals n = 5 mice).

^cMeans are significantly different from the control group (P < 0.05).

^dValues between parentheses: (percentage anti-inflammatory activity (AI%).