Table 3.
The protective effects of promising compounds and the reference drug, sulfasalazine against bacteremic infections in mice ED50 values in µmol/kg/day (95% confidence limit).
| organism | Challenge dose(CFU/mouse) | drug | ED50 (µmol/kg/day) | 95% confidence limit |
|---|---|---|---|---|
| Staphylococcus aureus | 9.5x106 | Sulfasalazine | 313.7 | (84.62 – 523.8) |
| 5b | 413.1 | (318.5 – 511.4) | ||
| 5j | 302.1 | (214.7 – 373.3) | ||
| 5n | 397.6 | (78.40 – 583.3) | ||
| 5o | 352.7 | (315.4 – 398.1) | ||
| Escherichia coli | 7.1x103 | sulfasalazine | 419.2 | (194.5 – 690.8) |
| 5b | 415.7 | (275.6 – 534.5) | ||
| 5j | 272.7 | (157.1 – 386.2) | ||
| 5n | 367.1 | (166.9 – 565.7) | ||
| 5o | 306.4 | (160.0 – 445.5) |